Samantha Manson is one of Danny Phantom's best friends
Sam appeared as a non-playable character in Nicktoons Unite!. When the heroes arrived in Amity Park to find their way to Vlad's Castle, they encountered Sam and Tucker. Sam explained that ghosts had overshadowed the inhabitants. Danny said they would clear the coast. Tucker said to meet at the Amity Park cemetery. When you arrive there, Sam says to cross the cemetery as shortcut to Vlad's castle.
Sam appeared as one of the many characters who could be photographed in Nicktoons: Freeze Frame Frenzy.
Sam appears as a playable character. She is found when the party comes to Calamity Cove. She was fighting some sand monsters in the Fenton Peeler Suit when the heroes arrived. She explained to Danny that she was testing the suit with Maddie in Amity Park when she suddenly was teleported to Volcano Island. Sam joins the group afterwards and defeat The Mawgu.
Sam normally attack by kicking her opponent. However when she grabs a battery she puts on the Fenton Peeler Suit and has infinite ghost energy shots for a limited time. The shots, in most cases, are in instant kill. Sam's special outfit is her in her Prom Dress from "Parental Bonding" which can be bought when she collected 200 Myster Tiki's. When you collect all of Sam's salvage items you unlock her bonus level; You Go Both which has a gothic theme.
Sam along with Danny were recruited into the team when Jimmy Neutron called Danny to investigate how Professor Calamitous got a hold of the ghost energy for his evil plans. Danny revealed that he was not home when the Professor and the toy minions broke into his home, but that now his place was surrounded by toys that resembled Sam and himself. Jimmy apparentaly had an idea to combat the toybots and told Danny to get Sam and meet up with the Nicktoons upon their arrival at Amity Park. Once the group meet, Jimmy and the other Nicktoons reveal how they plan to fight the toybots rampaging throughout Amity Park: Mech Suits! Sam is stunned by the suits and left speechless and also receives her own Mech Suit, a black one. The heroes fight their way through Amity Park using the suits with Sam stating how she wants payback for the destruction they caused.